Spending that much on Open Box would make me nervous a bit.
I'd agree with that. You should run a stability test on it for 24 hours just to make sure there aren't any problems. That should detect anything that might be concerning. There's always a possibility someone with money bought it and later replaced it with something that could OC better and that the card doesn't have much wear on it.
If it can handle 24 hours under load within specifications it's unlikely to have any problems crop up a few months from now.
